FRONTLINE Plus Flea & Tick Treatment Large Dog (20-40kg)

£26.02 £41.99 From £7.00 each
Please select a variant:
    3 Pipettes
    6 Pipettes
suitcase icon

This is a specialist veterinary product. We will ask you a simple set of questions to confirm that you are buying the correct medicine for your pet and know how to use it safely

Medicinal Category: NFA-VPS

FRONTLINE Plus is the most advanced formula within the FRONTLINE range of flea and tick treatments. It not only kills fleas, but also stops their eggs from hatching and infesting your home. Unlike other flea treatments, FRONTLINE Plus kills ticks too, helping to reduce the risk of tick-borne disease transmission. Use every 4 weeks all year round for optimum flea and tick protection.

- Kills fleas on your pet within 24 hours
- Stops flea eggs hatching in your home
- Kills ticks within 48 hours, helping reduce the risk of tick-borne diseases
- Kills lice

FRONTLINE Plus is a veterinary medicine with a robust safety profile. Large can be applied to dogs from 8 weeks of age that weigh 20-40 kg. It can also be used in pregnant and lactating bitches.

Bathing/shampooing/water exposure does not affect the efficacy of the product as long as it doesn't occur more than once a week. If your dog is unwell, please see your vet for advice before you apply a flea treatment. FRONTLINE Plus for dogs is not suitable for use on rabbits.

Available in 3 and 6 dose packs.

Key Benefits

Spot-on solution for dogs weighing 20-40 kg. Kills fleas, ticks and lice. Stops flea eggs from hatching. UK authorised veterinary medicinal product. 

Product Information

Detailed information on this veterinary medicine is available in the data sheet here and instructions will be included with the product. If you have questions about the use of this veterinary medicine, please contact us at or speak to your vet. Further information about veterinary medicines can be obtained from the Veterinary Medicines Directorate.

As this is a veterinary medicine, our Vet Team may on occasion contact you to ensure that this product is suitable for your pet.

Store below 25°C, in a dry place and in the original packaging.

Due to regulatory law and safety reasons this product cannot be returned after delivery and is excluded from our returns policy and exempt from the cool-off period.

Recommended for

For the treatment of dogs weighing 20-40 kg.

To be used against infestations with fleas, alone or in association with ticks and/or biting lice.

Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persist for 8 weeks.

Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity) and larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for eight weeks after application.

Treatment of tick infestations (Ixodes ricinus, Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus). The product has a persistent acaricidal efficacy for up to 4 weeks against ticks.

Treatment of infestations with biting lice (Trichodectes canis).

Active ingredient

Each pipette of 2.68 ml contains:

Active substances: 
Fipronil 268.00 mg
(S)-methoprene 241.20 mg

Butylhydroxyanisole (E320) 0.54 mg
Butylhydroxytoluene (E321) 0.27 mg


How to protect your dog:
Use monthly throughout the year for continuous flea and tick protection.
Make sure all cats and dogs in your home are treated regularly.

How to treat a home infestation:
Follow the 2 steps above as well as the 2 steps below.
Use a household flea treatment to kill eggs and larvae already in the home.
Regularly vacuum your carpets and furnishings.

Checklist for using the product:
The dog is at least 8 weeks old and 20kg.
The dog shows no signs of lesions or feeling unwell. If they show any of these signs, do not apply and see a veterinary surgeon.
The correct size of pipette is being selected according to the dog's weight.

How to apply:
Part the fur at the base of the neck in front of the shoulder blades and apply directly onto the skin in one spot.
Do not bathe animals within 2 days after application, then no more than once a week.
Can be used in pregnancy and lactation.

Dosage Guide

Large Dog (20-40kg) - 1 pipette of 2.68ml

Treatment Frequency:

Prevention of flea infestations - 8 weeks
Treatment of flea infestations - 4 weeks
Tick prevention/infestation - 4 weeks

Safety Advice

- For external use only
- For animal treatment only
- Do not use on rabbits
- Keep out of the sight and reach of children

Wash hands after use. Avoid direct contact with the skin and eyes. Wear gloves if you have any known hypersensitivity to the product.

Store below 25 degrees and out of direct sunlight.